CV
I am a final year medical student at the University of Cambridge interested in research and medical education. Currently, I am involved in researching outcomes in cardiac surgery at the Royal Papworth Hospital and hold several teaching commitments across the University of Cambridge and its colleges, instructing undergraduate natural scientists, pre-clinical and clinical medical students.
I obtained an undergraduate research degree in Physiology, and my project investigated murine models of inherited arrhythmic syndromes and the effects of metabolic derangement on arrhythmogenic substrate formation. This work has since been published in peer-reviewed journals. Extra-curricular interests of mine include distance running, astronomy, and aviation/flight simulators.
2.i Physiology, development and neuroscience
4 A*s (Biology, Chemistry, Mathematics and Physics)
For a full list of publications click on this link.
Original research
Fazmin IT, Rafiq MU, Nashef SA, Ali JM. Inferior outcomes following cardiac surgery in patients with a functioning renal allograft. Interactive CardioVascular and Thoracic Surgery. 2020 September. PMID:33212501. DOI:10.1093/icvts/ivaa245.
Saadeh K, Achercouk Z, Fazmin IT, Nantha Kumar N, Salvage SC, Edling CE, Huang CLH, Jeevaratnam K. Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex. Annals of the New York Academy of Sciences. 2020 Jul 26. PMID 32713021 DOI:10.1111/nyas.14426
Edling CE, Fazmin IT, Saadeh K, Chadda KR, Ahmad S, Valli H, Huang CL, Jeevaratnam K. Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor gamma coactivator deficient (Pgc-1β-/-) hearts modelling mitochondrial dysfunction. Bioscience reports. 2019 Nov. PMID:31778152. DOI:10.1042/BSR20190403
Edling CE, Fazmin IT, Chadda K, Ahmad S, Valli H, Huang C, Jeevaratnam K. Atrial transcriptional profiles of molecular targets mediating electrophysiological function in ageing and Pgc-1β deficient murine hearts. Frontiers in Physiology. 2019;10:497. PMID:31068841. DOI:10.3389/fphys.2019.00497.
Edling CE, Fazmin IT, Chadda KR, Ahmad S, Valli H, Grace AA, Huang CL, Jeevaratnam K. Ageing in Pgc-1β-/-mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology. Bioscience Reports. 2019 Mar 26:BSR20190127. PMID:30914453. DOI:10.1042/BSR20190127.
Review articles
Abu-Omar Y, Fazmin IT, Ali JM, Pelletier MP. Minimally invasive mitral valve surgery. Journal of Thoracic Disease. 2020. In press (JTD-20-2114).
Fazmin IT, Achercouk Z, Edling CE, Said A, Jeevaratnam K. Circulating microRNA as a Biomarker for Coronary Artery Disease. Biomolecules. 2020 Sep 23. PMID:32977454. DOI:10.3390/biom10101354.
Fazmin IT, Huang CL, Jeevaratnam K. Bisphosphonates and atrial fibrillation: revisiting the controversy. Annals of the New York Academy of Sciences. 2020 Mar 24. PMID:32208537 DOI:10.1111/nyas.14332
Chadda KR, Fazmin IT, Ahmad S, Valli H, Edling CE, Huang CL, Jeevaratnam K. Arrhythmogenic mechanisms of obstructive sleep apnea in heart failure patients. Sleep. 2018 Jul 16;41(9):zsy136. PMID:30016501. DOI:10.1093/sleep/zsy136.
Letters
Fazmin IT, Ali JM. Re-exploration and bleeding rates after cardiac surgery can be reduced-The utility of a checklist. J Card Surg. 2020. PMID:33135219 DOI:10.1111/jocs.15142
Fazmin IT, Rafiq MU, Nashef SA, Ali JM. Inferior survival following cardiac surgery in patients with a functioning renal allograft. Cambridge National Cardiology Conference 2020, organised by the Cambridge University Cardiology Society, February 2020, Cambridge, UK
Fazmin IT, Edling CE, Saadeh K, Chadda KR, Valli H, Ahmad S, Huang CLH, Jeevaratnam K. Transcriptional and protein expression changes associated with pro-arrhythmic phenotypes in ageing and Pgc-1β knockout murine models of mitochondrial dysfunction. 4th EU-CardioRNA Working Group Meeting, February 2020, Maastricht, The Netherlands
Fazmin IT, Zhang RY, Porto A, Divulwewa K, Reddy A, Gonzalez-Panizo J, di Nubila B, Mausa MF, Agarwal S, Begley D, Flynn S, Grace A, Heck P, Mellor G, Virdee M, Martin CA. Improved outcome in ablation of ventricular tachycardia in patients with structural heart disease under general anaesthetic. Heart Rhythm Congress 2019, organised by the British Heart Rhythm Society and Arrhythmia Alliance, October 2019, Birmingham, UK
Fazmin IT, Edling CE, Chadda KR, Ahmad S, Valli H, Huang CLH, Jeevaratnam K. Molecular basis of arrhythmic substrate in ageing, Pgc-1β-deficient, murine hearts modelling mitochondrial dysfunction. Europhysiology 2018, organised by the Physiological Society, September 2018, London, UK
*Winner, Rob Clarke Silver Award for Undergraduate Research*
Undergraduate Supervisor
Formal teaching appointment for small group teaching for first-year medical students and second-year natural scientists on course content and exam preparation. Underwent centrally organised training by the University of Cambridge Centre for Teaching and Learning and am accredited for teaching life sciences at the undergraduate level.
Courses taught: Medical Sciences Tripos, Part 1A - Homeostasis (Physiology); Natural Sciences Tripos, Part 1B - Physiology.
Colleges taught: Churchill College, Girton College, Homerton College, Magdalene College, Trinity College
2019: "Concepts at a Glance: Cardiology", Cambridge University Cardiology Society
Conceptualised and delivered an introductory lecture on core cardiology concepts to fourth year clinical medical students in collaboration with the Cambridge University Medical Education Society.
2019-Present: Associate Clinical Supervisor
Formal teaching appointment, teaching fourth year Student Doctors clinical examination skills.
2019-Present: Intermediate Clinical Supervisor
Ward based teaching aimed at third year pre-clinical medical students to get them comfortable interacting with patients in a clinical setting.
2019-Present: Preparing for Patients B Facilitator
Formal teaching appointment, ward based teaching for second year pre-clinical medical students, teaching them communication skills. This was followed by leading a debrief session to reflect on lessons learnt and areas to improve upon.
Heartstart Instructor
Certified instructor for teaching CPR and basic emergency life saving skills to members of the public.
2018 Rob Clark Silver Award for Undergraduate Research
The Physiological Society, UK
2017 Biomedical Vacation Scholarship
Wellcome Trust
2017 Prize Scholarship
Churchill College, University of Cambridge
2017 Medical and Veterinary Prize
Churchill College, University of Cambridge
2014 Best A Level Results
The British School in Colombo
2012 Sixth Form Tuition Fee Scholarship
The British School in Colombo
Introductory seminar for fourth year medical students, detailing best practices in choosing a student selected component.
Visiting Research Associate
I work in the lab of Dr Kamalan Jeevaratnam, studying cardiac arrhythmogenesis in murine models. I am trained in molecular biology techniques such as tissue protein extraction, Western blotting, and histological protein quantification. I am also experienced in scientific writing, having coauthored a review article and prepared abstracts and posters for conferences. Additionally, I trained new members of the laboratory in experimental techniques.